| Team: | Siena | Rating: | 0.4483 | Average Socre: | 66.2759 |
| Conference: | Metro Atlantic | ||||
| Wins: | 15 | Losses: | 14 | Div 1 Games: | 29 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 48 | St. Bonaventure (20 - 9) | 47 | 75 | |
| 11/13/2021 | L | 91 | Delaware (22 - 12) | 63 | 83 | ||
| 11/16/2021 | L | 101 | Yale (19 - 11) | 54 | 82 | ||
| 11/19/2021 | L | at | 303 | Georgetown (6 - 25) | 65 | 83 | |
| 11/22/2021 | W | 223 | Harvard (13 - 13) | 72 | 69 | ||
| 11/28/2021 | L | at | 324 | Bucknell (9 - 23) | 56 | 65 | |
| 11/30/2021 | W | at | 235 | Army (15 - 16) | 83 | 67 | |
| 12/03/2021 | L | 216 | Manhattan (15 - 15) | 72 | 77 | ||
| 12/05/2021 | W | at | 95 | Saint Peter's (19 - 11) | 60 | 58 | |
| 12/11/2021 | W | at | 341 | Holy Cross (9 - 22) | 72 | 59 | |
| 01/09/2022 | W | 222 | Fairfield (15 - 18) | 69 | 62 | ||
| 01/14/2022 | W | at | 207 | Marist (14 - 16) | 67 | 60 | |
| 01/21/2022 | L | at | 216 | Manhattan (15 - 15) | 68 | 75 | |
| 01/25/2022 | L | at | 25 | Iona (25 - 7) | 57 | 74 | |
| 01/28/2022 | W | 211 | Niagara (14 - 16) | 60 | 56 | ||
| 01/30/2022 | W | 228 | Quinnipiac (14 - 17) | 85 | 76 | ||
| 02/01/2022 | W | 270 | Canisius (11 - 21) | 73 | 65 | ||
| 02/04/2022 | L | 252 | Rider (14 - 19) | 60 | 74 | ||
| 02/06/2022 | W | at | 222 | Fairfield (15 - 18) | 62 | 56 | |
| 02/11/2022 | W | 25 | Iona (25 - 7) | 70 | 64 | ||
| 02/13/2022 | W | at | 252 | Rider (14 - 19) | 76 | 75 | |
| 02/18/2022 | L | 207 | Marist (14 - 16) | 53 | 62 | ||
| 02/20/2022 | W | 95 | Saint Peter's (19 - 11) | 84 | 70 | ||
| 02/22/2022 | L | at | 94 | Monmouth (21 - 13) | 59 | 71 | |
| 02/24/2022 | W | at | 228 | Quinnipiac (14 - 17) | 78 | 71 | |
| 02/27/2022 | W | 94 | Monmouth (21 - 13) | 70 | 59 | ||
| 03/03/2022 | L | at | 211 | Niagara (14 - 16) | 52 | 74 | |
| 03/05/2022 | L | at | 270 | Canisius (11 - 21) | 64 | 67 | |
| 03/10/2022 | L | 228 | Quinnipiac (14 - 17) | 71 | 77 | Atlantic City, NJ |